HB Yapanga Njira Yatsopano Yosungira Zitsanzo Zachilengedwe ku ICL

Imperial College London (ICL) ili patsogolo pa kafukufuku wa sayansi ndipo, kudzera mu Dipatimenti ya Immunology ndi Inflammation ndi Dipatimenti ya Ubongo Sciences, kafukufuku wake umayambira pa rheumatology ndi hematology mpaka matenda a dementia, matenda a Parkinson ndi khansa ya ubongo. Kuyang'anira kafukufuku wosiyanasiyana wotere kumafuna malo apamwamba kwambiri, makamaka osungira zitsanzo zofunika kwambiri zamoyo. Neil Galloway Phillipps, Senior Lab Manager wa madipatimenti onse awiri, adazindikira kufunika kwa njira yosungira cryogenic yogwira ntchito bwino komanso yokhazikika.

Zosowa za ICL

1.Dongosolo losungiramo nayitrogeni wamadzimadzi lokhala ndi mphamvu zambiri komanso logwirizana

2.Kuchepetsa kugwiritsa ntchito nayitrogeni ndi ndalama zogwirira ntchito

3.Kulimbitsa chitetezo cha zitsanzo ndi kutsatira malamulo

4.Ofufuza angapeze mosavuta komanso motetezeka

5.Yankho lokhazikika lothandizira njira zobiriwira

Mavuto

Dipatimenti ya Immunology ya ICL kale inkadalira nitrogen yamadzimadzi 13 yosiyana (LN)₂) matanki osungira zitsanzo za mayeso azachipatala, maselo a satellite ndi maselo oyambira. Dongosolo logawanikali linkatenga nthawi kuti likonzedwe, ndipo linkafuna kuyang'aniridwa ndi kudzazidwanso nthawi zonse.

"Kudzaza matanki 13 kunatenga nthawi yayitali, ndipo kusunga zonse zinali zovuta kwambiri," anafotokoza Neil. "Zinali zovuta kwambiri pankhani ya kayendetsedwe ka zinthu, ndipo tinkafunika njira yothandiza kwambiri yosamalira malo athu osungiramo zinthu."

Vuto lina linali mtengo wosamalira matanki angapo.₂Kugwiritsa ntchito zinthu kunali kwakukulu, zomwe zinapangitsa kuti ndalama zogwirira ntchito zikwere. Nthawi yomweyo, kuwononga chilengedwe chifukwa cha kuperekedwa kwa nayitrogeni pafupipafupi kunali kosagwirizana ndi kudzipereka kwa labu pakupereka zinthu zokhazikika. "Takhala tikugwira ntchito kuti tipeze mphoto zosiyanasiyana zokhazikika, ndipo tinkadziwa kuti kuchepetsa kugwiritsa ntchito nayitrogeni kungapangitse kusiyana kwakukulu," adatero Neil.

Chitetezo ndi kutsatira malamulo zinali zofunika kwambiri. Popeza matanki ambiri anali kufalikira m'malo osiyanasiyana, kutsatira njira zopezera ndi kusunga zolemba zatsopano kunali kovuta. "Ndikofunikira kuti tidziwe bwino omwe akupeza zitsanzozo, komanso kuti chilichonse chisungidwe bwino mogwirizana ndi malamulo a Human Tissue Authority (HTA)," Neil adawonjezera. "Dongosolo lathu lakale silinapangitse zimenezo kukhala zosavuta."

Yankho

ICL inali kale ndi zida zosiyanasiyana kuchokera ku Haier Biomedical - kuphatikizapo malo osungira zinthu zozizira, makabati oteteza zachilengedwe, CO₂zoyatsira ndi zoyezera kutentha - kukulitsa chidaliro mu mayankho a kampani.

Choncho Neil ndi gulu lake adapita kwa Haier Biomedical kuti athandize kuthana ndi mavuto atsopanowa, poyika CryoBio 43 LN yokhala ndi mphamvu zambiri.₂biobank kuti iphatikize matanki onse 13 osasinthika kukhala njira imodzi yogwirira ntchito bwino kwambiri. Kusinthaku kunali kosalala, gulu la Haier likuyang'anira kukhazikitsa ndikuphunzitsa ogwira ntchito mu labotale. Dongosolo latsopanoli linalowa mu LN yomwe ilipo₂malo okhala ndi zosintha zazing'ono zokha. Popeza dongosolo latsopanoli lakhazikitsidwa, kusungira ndi kuyang'anira zitsanzo kwakhala kogwira mtima kwambiri. "Ubwino umodzi wosayembekezereka unali kuchuluka kwa malo omwe tinapeza," adatero Neil. "Matanki akale onse atachotsedwa, tsopano tili ndi malo ambiri mu labotale kuti tigwiritse ntchito zida zina."

Kusintha kwa malo osungiramo zinthu pogwiritsa ntchito nthunzi kwawonjezera chitetezo komanso kugwiritsa ntchito mosavuta. "Kale, nthawi iliyonse tikatulutsa choyikamo mu thanki yokhala ndi madzi, chinkatulutsa nayitrogeni, zomwe nthawi zonse zinali zodetsa nkhawa. Tsopano, ndi malo osungiramo zinthu pogwiritsa ntchito nthunzi, ndi zoyera komanso zotetezeka kugwiritsa ntchito zitsanzo. Njira yopezera zinthu pogwiritsa ntchito biometric yalimbitsanso chitetezo ndi kutsatira malamulo chifukwa timatha kutsatira bwino amene akugwiritsa ntchito njira imeneyi komanso nthawi yake."

Neil ndi gulu lake adapeza kuti makinawa ndi osavuta kugwiritsa ntchito, ndipo pulogalamu yophunzitsira ya Haier idawathandiza kuti azitha kugwiritsa ntchito mosavuta.

Chinthu chosayembekezereka koma cholandiridwa chinali masitepe obwezeretseka okha, zomwe zimapangitsa kuti kulowa mu thankiyo kukhale kosavuta. "Ndi matanki am'mbuyomu, ofufuza nthawi zambiri ankafunika kunyamula zinthu zonse. Ngakhale kuti thanki yatsopanoyo ndi yayitali, masitepewo amagwira ntchito podina batani, zomwe zimapangitsa kuti kuwonjezera kapena kuchotsa zitsanzo zikhale zosavuta kuzisamalira," Neil adatero.

Kusunga zitsanzo zamtengo wapatali

Zitsanzo zomwe zasungidwa ku malo osungira zinthu a ICL ndi zofunika kwambiri pa kafukufuku amene akuchitika. "Zina mwa zitsanzo zomwe timasunga sizingasinthidwe konse," anatero Neil.

"Tikulankhula za kukonzekera maselo oyera amagazi kuchokera ku matenda osowa, zitsanzo za mayeso azachipatala, ndi zinthu zina zofunika kwambiri pa kafukufuku. Zitsanzozi sizimangogwiritsidwa ntchito mu labu; zimagawidwa ndi ogwira nawo ntchito padziko lonse lapansi, zomwe zimapangitsa kuti umphumphu wawo ukhale wofunika kwambiri. Kugwira ntchito kwa maselo awa ndikofunika kwambiri. Ngati sanasungidwe bwino, kafukufuku amene amathandizira akhoza kusokonekera. Ndicho chifukwa chake tikufunika malo osungira ozizira odalirika kwambiri omwe tingawadalire. Ndi dongosolo la Haier, tili ndi mtendere wamumtima. Titha kuwona kutentha kwa thupi nthawi iliyonse, ndipo ngati titawunikidwa, tingasonyeze motsimikiza kuti chilichonse chasungidwa bwino."

 Kukonza kukhazikika kwa zinthu komanso kugwiritsa ntchito bwino ndalama

Kuyambitsidwa kwa biobank yatsopano kwachepetsa kwambiri kugwiritsa ntchito nayitrogeni yamadzimadzi mu labotale, ndikuchepetsa kuwirikiza kakhumi. "Thanki iliyonse yakaleyo inali ndi malita pafupifupi 125, kotero kuiphatikiza kwapanga kusiyana kwakukulu," Neil anafotokoza. "Tsopano tikugwiritsa ntchito gawo laling'ono la nayitrogeni yomwe tinkagwiritsa ntchito kale, ndipo imeneyo ndi kupambana kwakukulu pazachuma komanso zachilengedwe."

Popeza kufunikira kwa nayitrogeni yochepa, mpweya woipa wa kaboni wachepa, zomwe zathandiza zolinga za labu zosamalira chilengedwe. "Sizokhudza nayitrogeni yokha," Neil adawonjezera. "Kukhala ndi kunyamula kochepa kumatanthauza kuti magalimoto ochepa ali pamsewu, komanso mphamvu zochepa zomwe zimagwiritsidwa ntchito popanga nayitrogeni poyamba." Kusintha kumeneku kunali kofunika kwambiri kotero kuti Imperial idalandira mphoto zosamalira chilengedwe kuchokera ku LEAF ndi My Green Lab pozindikira khama lake.

Mapeto

Banki yosungiramo zinthu zakale ya Haier Biomedical yasintha kwambiri luso la ICL losungiramo zinthu, kukonza magwiridwe antchito, chitetezo, komanso kukhazikika kwa zinthu, komanso kuchepetsa ndalama. Chifukwa chotsata malamulo bwino, chitetezo cha zitsanzo komanso kuchepetsa kuwonongeka kwa chilengedwe, kusinthaku kwakhala kopambana kwambiri.

Zotsatira za Pulojekiti

1.LN₂kugwiritsa ntchito kwachepetsedwa ndi 90%, zomwe zimachepetsa ndalama ndi mpweya woipa

2.Kutsata zitsanzo bwino komanso kutsatira malamulo a HTA

3.Kusungirako nthunzi m'malo otetezeka kwa ofufuza

4.Kuchuluka kwa malo osungira zinthu mu dongosolo limodzi

5.Kuzindikiridwa kudzera mu mphoto zokhazikika